A set of functionally-defined brain regions with improved representation of the subcortex and cerebellum

읽은 날	2020.08.18	학술지	NeuroImage
제목	A set of functionally-defined brain regions with improved representation of the subcortex and cerebellum
저자	Benjamin A. Seitzman a,*, Caterina Gratton a, Scott Marek a, Ryan V. Raut c, Nico U.F. Dosenbach a,c,d, f,g, Bradley L. Schlaggar a,b,c,d,e, Steven E. Petersen a,h,c,e,g, Deanna J. Greene b,c
한줄요약	Subcortex와 Cerebellum의 functionality map 제작.
초록	An important aspect of network-based analysis is robust node definition. This issue is critical for functional brain network analyses, as poor node choice can lead to spurious findings and misleading inferences about functional brain organization. Two sets of functional brain nodes from our group are well represented in the literature: (1) 264 volumetric regions of interest (ROIs) reported in Power et al., 2011, and (2) 333 cortical surface parcels reported in Gordon et al., 2016. However, subcortical and cerebellar structures are either incompletely captured or missing from these ROI sets. Therefore, properties of functional network organization involving the subcortex and cerebellum may be underappreciated thus far. Here, we apply a winner-take-all partitioning method to resting-state fMRI data to generate novel functionally-constrained ROIs in the thalamus, basal ganglia, amygdala, hippocampus, and cerebellum. We validate these ROIs in three datasets using several criteria, including agreement with existing literature and anatomical atlases. Further, we demonstrate that combining these ROIs with established cortical ROIs recapitulates and extends previously described functional network organization. This new set of ROIs is made publicly available for general use, including a full list of MNI coordinates and functional network labels.
키워드	Subcortical, Cerebellum, Networks, Resting-state, Functional connectivity
의의	Cortical area에 비해 부족하던 subcortical area와 cerebellum에 대한 functional map을 제시함.
비판점