An fMRI study on mental pain and suicidal behavior

읽은 날	2020.08.10	학술지	Journal of Affective Disorder
제목	An fMRI study on mental pain and suicidal behavior
저자	Thomas Reisch a , Erich Seifritz b , Fabrizio Esposito c , Roland Wiest d , Ladislav Valach e , Konrad Michel a, ⁎
한줄요약	Both, mPFC and the ACC play a central role in the regulation of emotional and behavioral responses to stressful events.
초록	Background: Suicide is a poorly understood phenomenon. A clinical model of suicide conceptualizes suicidal behavior as a solution to an unbearable state of mind, experienced as mental pain. Methods: In order to investigate the neural correlates of suicidal behavior, we used fMRI during presentation of autobiographical scripts extracted from personal narratives reactivating patients' memories of a recent episode of attempted suicide. Brain activation was measured during three recalled conditions: mental pain, suicide action, and neutral activity. Results: Recall of suicidal episodes, that is, mental pain plus suicide action, compared to neutral activity, was associated with deactivation in the prefrontal cortex (BA 6, 10, and 46). Recall of suicide action, however, compared to mental pain, was associated with increased activity in the medial prefrontal cortex, the anterior cingulate cortex, and the hippocampus. Limitations: This is a pilot study with eight female subjects. Conclusions: Clinical and fMRI data suggest that mental pain triggering suicidal behavior may have the quality of traumatic stress, associated with decreased prefrontal activity. Planning and acting out suicidal impulses in response to mental pain, however, is associated with increased activity in the frontal cortex, suggesting that goal-directed suicidal behavior is associated with a reduction of mental pain.
키워드	Suicide Attempted suicide Mental pain Suicide action Suicidal mode Dissociation Neuroimaging
의의	자살 생각이나 실제 자해행동 시 뇌 활동을 비교하여 차이를 보임.
비판점	자살에 대한 생각이 없는 순수 stressful pain을 가진 control은 찾기 어려워 within-subject design만 비교.