Neuroimaging Correlates of Depression—Implications to Clinical Practice

읽은 날	2020.07.27	학술지	frontiers in psychiatry
제목	Neuroimaging Correlates of Depression—Implications to Clinical Practice
저자	Lígia Castanheira 1,2, Carlos Silva 1, Elie Cheniaux 3 and Diogo Telles-Correia 1,2*
한줄요약	여러 neuroimaging(fMRI, sMRI, PET...)를 이용한 MDD의 기능적, 구조적 증상 review
초록	The growth of the literature about neuroimaging of major depressive disorder (MDD) over the last several decades has contributed to the progress in recognizing precise brain areas, networks, and neurotransmitter processes related to depression. However, there are still doubts about the etiology and pathophysiology of depression that need answering. The authors did a nonsystematic review of the literature using PubMed database, with the following search terms: “major depressive disorder,” “neuroimaging,” “functional imaging,” “magnetic resonance imaging,” “functional magnetic resonance imaging,” and “structural imaging,” being selected the significant articles published on the topic. Anterior cingulate cortex, hippocampus, orbitomedial prefrontal cortex, amygdala basal ganglia, and the cerebellum were the main affected areas across the selected studies. These areas respond to particular neurotransmitter systems, neurochemicals, hormones, and other signal proteins; even more, the evidence supports a distorted frontolimbic mood regulatory pathway in MDD patients. Despite the positive findings, translation to treatment of MDD remains illusory. In conclusion, this article aims to be a critical review of the neuroimaging correlates of depression in clinical research with the purpose to improve clinical practice.
키워드	Major depressive disorder(MDD), fMRI, sMRI, PET
의의	여러 MDD 관련 논문들의 neuroimaging 방법, 밝혀낸 관련 증상 등을 광범위하게 리뷰함.
비판점	리뷰한 논문들의 subject가 많은 수가 아니라 general population에 적용시키기엔 부족하다.