Randomized Clinical Trial of Real-Time fMRI AmygdalaNeurofeedbackfor Major Depressive Disorder: EffectsonSymptoms and Autobiographical Memory Recall

읽은 날	2020.07.20.	학술지	Medical knowledge
제목	Randomized Clinical Trial of Real-Time fMRI Amygdala Neurofeedbackfor Major Depressive Disorder: Effectson Symptoms and Autobiographical Memory Recall
저자	Kymberly D. Young, Ph.D., Greg J. Siegle, Ph.D., Vadim Zotev, Ph.D., Raquel Phillips, B.S., Masaya Misaki, Ph.D., Han Yuan, Ph.D., Wayne C. Drevets, M.D., Jerzy Bodurka, Ph.D.
한줄요약	rtfMRI amygdala neurofeedback로 positive memory에 대한 HRF를 증가시키는 방법은  major depressive disorder 개선에 효과가 있다.
초록	Depression is a common and disabling condition (1). With approximately two-thirds of patients not responding fully to treatment (2), investigation into novel therapeutic approaches is warranted. One novel approach is real-time functional MRI neurofeedback (rtfMRI-nf ), in which an individual receives information about the blood-oxygen-level-dependent (BOLD) signal from their brain in real time and learns to selfmodulate this signal (3, 4). Emerging evidence suggests that rtfMRI-nf has clinical utility in chronic pain (5), smoking cessation (6), anxiety (7), and depression (8, 9). In the present study, we conducted a randomized clinical trial to test the therapeutic potential of rtfMRI-nf training to enhance the amygdala hemodynamic response to positive autobiographical memory recall for depression.
키워드	amygdala neurofeedback, MDD(Major depressive disorder)
의의	우울증 증상을 neurofeedback으로 완화시킬 수 있다는 실험적인 증명. 항우울제 처방이나 cognitive-behavioral therapy을 사용한 효과와 비교해도 유의미한 수준.
비판점	Positive memory에 대한 정량적 측정(가능하다면) 필요. HRF 측정을 통해 어느정도의 positive한 memory가 얼마나 영향을 미치는지 측정할 수 있을 것 같다.